![]() These example sentences are selected automatically from various online news sources to reflect current usage of the word 'chaperone.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. , 20 July 2019 Fleury Drive resident Cameron Drew expressed concerns about how well Black might be able to chaperone a group of teenagers.Īnnie Gentile,, 19 July 2019 Tena’s older sister, who lives near Sacramento, would drive two-and-a-half hours south to Salinas to pick her up, take her to the meetings, then chaperone her home again-eight hours of driving each time. 2019 Students came to us and asked us to chaperone them to Europe for six weeks. 2019 King was prepared to chaperone the trip and carry her daughter the whole way, but someone reached out with a suggestion.Ĭaitlin O'kane, CBS News, 24 Sep. 2019 Attendees must be 22 or younger, although parents may chaperone their teens. 2021 Some people would rather chaperone the Zombie Prom than ask for a bump in pay.Īmy Lindgren, Twin Cities, 26 Oct. 2022 The field trip has happened for a decade, but went largely unnoticed until this week, when Leonardi posted photos on social media saying she was honored to chaperone it. Verb All that changes when she is forced to chaperone her autistic sister. 2022 Sowa also didn’t have a chaperone for the appointment with that female patient.Īmanda Milkovits,, 2 Sep. Kelly Meyerhofer, Journal Sentinel, 16 Sep. 2022 For now, as the bots learn the lay of the land, a chaperone will accompany them on deliveries that involve crossing a street. 2022 Oaks Park, the venerable amusement park located in Southeast Portland, has instituted a new chaperone policy for its skating rink. 2022 In 2016, the board unanimously rejected a request from Gupta to drop the chaperone requirement because, his lawyer said, the restriction was keeping Gupta from gaining privileges at a hospital. Melissa Gomez, Los Angeles Times, 28 Sep. 2012 The theme park instituted the chaperone policy after multiple fights broke out and forced the park to close three hours early in July. 2022 According to depositions from Kappes and other students on the trip, the only other chaperone was Coleman’s friend David DeMetz, a paramedic in his mid-twenties. 2022 Starting Thursday, any chaperone who attends Knott’s Scary Farm at the Buena Park theme park with five minors will be given complimentary admission to use that same night. An older person who accompanies other younger people to ensure the propriety of their behaviour, often an older woman accompanying a young woman. ![]() Mutation studies indicate that client binding, interactions between Hsp40 and Hsp70, plus ATP hydrolysis by Hsp70 are all required to promote conformational maturation of PR via the Hsp90 pathway.Noun The whole school was invited to join the ride, and about 75 students showed up, many bringing their parents along to help chaperone. Ydj1 and DjA1 bind tightly to PR whereas the binding of DjB1 apparently has rapid on and off rates and its binding cannot be observed by antibody pull-down methods using either purified proteins or cell lysates. The type I proteins, Ydj1 and DjA1 (HDJ2), and a type II, DjB1 (HDJ1), act similarly in promoting hormone binding and Hsp70 association to PR, while having different binding characteristics to PR. We compared type I and type II Hsp40 proteins and created point mutations in Hsp40 and Hsp70 to understand the requirements for this first step. It was recently shown that the first step for the recognition of PR by this system is binding by Hsp40. The addition of these proteins is necessary to reconstitute hormone-binding capacity to the immuno-isolated PR. This chaperoning pathway can be reconstituted in vitro with the addition of five proteins plus ATP: Hsp40, Hsp70, Hop, Hsp90, and p23. The Hsp90 chaperoning pathway and its model client substrate, the progesterone receptor (PR), have been used extensively to study chaperone complex formation and maturation of a client substrate in a near native state.
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